Perforin-1 - CISMeF

Preferred Label : Perforin-1;

NCIt synonyms : Cytolysin; P1; PFP; Lymphocyte Pore-Forming Protein; PRF1;

NCIt definition : Perforin-1 (555 aa, 61 kDa) is encoded by the human PRF1 gene. This protein is involved in the mediation of cytolysis of infected cells.;

Details

Origin ID

C97741;

UMLS CUI

C1622765;

Automatic exact mappings (from CISMeF team)
- P1 Ag [LOINC component]
- Perforin [LOINC component]
- Perforin 1 [OMIM gene]
- cytolysins [MeSH concept]
- perforin [MeSH Descriptor]
False automatic mappings
- primary prevention [Q-code]
OMIM relation
- Perforin 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- PRF1 protein, human [MeSH concept]
- PRF1 protein, human [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- PRF1 protein, human [MeSH concept]
- PRF1 protein, human [MeSH Supplementary Concept]
Validated automatic mappings to NTBT
- cytotoxins [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Immunoprotein Gene [NCIt concept]
- PRF1 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
gene_product_has_structural_domain_or_motif
- C2 Domain [NCIt concept]
- EGF-Like Domain [NCIt concept]
gene_product_is_element_in_pathway
- Autoimmune Thyroid Disease Pathway [NCIt concept]
- CTL-mediated Immune Response Pathway [NCIt concept]
- Caspase Cascade Pathway [NCIt concept]
- Caspase Cascade in Apoptosis [NCIt concept]
- D4-GDI Signaling Pathway [NCIt concept]
- Downstream Signaling Pathway in Naive CD8+ T Cells [NCIt concept]
- Graft-Versus-Host Disease Pathway [NCIt concept]
- Granzyme A Mediated Apoptosis Pathway [NCIt concept]
- IL12/STAT4 Signaling Pathway [NCIt concept]
- IL2/STAT5 Signaling Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells [NCIt concept]
- Type I Diabetes Mellitus Pathway [NCIt concept]
- Viral Myocarditis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Antitumor Response [NCIt concept]
- Antiviral Response [NCIt concept]
- Apoptosis [NCIt concept]
- Cell-Mediated Cytotoxicity [NCIt concept]
- Immune System Process [NCIt concept]
- Positive Regulation of Cytolytic Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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