AKT Signaling Pathway

Preferred Label : AKT Signaling Pathway;

Alternative definition : BIOCARTA: Many cell-surface receptors induce production of second messengers like PIP3, phosphatidylinositol 3,4,5-trisphosphate, that convey signals to the cytoplasm from the cell surface. PIP3 signals activate the kinase PDK1, 3-phosphoinositide-dependent protein kinase-1, which in turn activates the kinase AKT, also known as protein kinase B. Proteins phosphorylated by activated AKT promote cell survival. Phosphorylation of Ikappa-B kinase leads to activation of the transcription factor NF-kB to oppose apoptosis. Bad is a protein in the Bcl-2 gene family that opposes Bcl-2 to induce apoptosis. Phosphorylation of Bad by AKT blocks anti-apoptotic activity to promote cell survival. Similarly, phosphorylation of the protease caspase 9 or forkhead transcription factors by AKT block the induction of apoptosis by these factors. AKT promotes cell survival and opposes apoptosis by a variety of routes. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_aktPathway;

Details

Origin ID

C38981;

UMLS CUI

C1515844;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- 3-Phosphoinositide-Dependent Protein Kinase 1 [NCIt concept]
- Activated Caspase-9 [NCIt concept]
- Bcl2 Antagonist of Cell Death [NCIt concept]
- Caspase-9 [NCIt concept]
- Forkhead Box Protein O1 [NCIt concept]
- Forkhead Box Protein O3 [NCIt concept]
- Forkhead Box Protein O4 [NCIt concept]
- Growth Hormone Receptor [NCIt concept]
- Heat Shock Protein HSP 90-Alpha [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Alpha [NCIt concept]
- NF-Kappa-B Inhibitor Alpha [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Alpha Isoform [NCIt concept]
- Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B'' Subunit Beta [NCIt concept]
- Somatotropin [NCIt concept]
- Transcription Factor p65 [NCIt concept]
- Tumor Necrosis Factor Ligand Superfamily Member 6 [NCIt concept]
pathway_has_gene_element
- AKT1 wt Allele [NCIt concept]
- BAD wt Allele [NCIt concept]
- CASP9 wt Allele [NCIt concept]
- CHUK wt Allele [NCIt concept]
- FASLG wt Allele [NCIt concept]
- FOXO1 wt Allele [NCIt concept]
- FOXO3 wt Allele [NCIt concept]
- FOXO4 wt Allele [NCIt concept]
- GH1 wt Allele [NCIt concept]
- GHR wt Allele [NCIt concept]
- HSP90AA1 wt Allele [NCIt concept]
- NFKBIA wt Allele [NCIt concept]
- PDPK1 wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PPP2CA wt Allele [NCIt concept]
- PPP2R3B wt Allele [NCIt concept]
- RELA wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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