Forkhead Box Protein O4

Preferred Label : Forkhead Box Protein O4;

NCIt synonyms : MLLT7; FOXO4; Fork Head Domain Transcription Factor AFX1; AFX1; AFX; Trithorax Homolog 7; Forkhead Box Protein-O4 Protein;

NCIt definition : Forkhead box protein O4 (505 aa, 54 kDa) is encoded by the human FOXO4 gene. This protein plays a role in cell cycle arrest, transcriptional regulation, embryonic development and insulin signaling.;

NCIt note : Forkhead Box Protein O4 is highly similar to forkhead transcription factor FKHR protein within its single forkhead domain and contains serine- and proline-rich regions like ENL protein. AFX-like proteins appear involved in cell cycle regulation. MLLT7 appears to block cell cycle progression at G1, independent of Rb but dependent on p27(KIP1). MLLT7 transcriptionally activates p27(KIP1). MLLT7 may also play a role in the insulin signaling pathway. Acute leukemia chromosomal translocation t(X;11)(q13;q23) involves MLLT7 fused to MLL/HRX that encodes a chimeric rogue activator protein.;

Details

Origin ID

C33948;

UMLS CUI

C1333634;

OMIM relation
- Forkhead box o4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- FOXO4 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- FOXO Family [NCIt concept]
gene_product_has_structural_domain_or_motif
- Forkhead Box [NCIt concept]
gene_product_is_element_in_pathway
- AKT Signaling Pathway [NCIt concept]
- FOXO Transcription Factor Family Signaling Pathway [NCIt concept]
- HDAC Class III Signaling Pathway [NCIt concept]
- Ras Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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