FOXO Family - CISMeF

Preferred Label : FOXO Family;

NCIt synonyms : Forkhead Box Transcription Factor Class O; Fork Head Box Transcription Factor Class O; FoxO;

NCIt definition : A subfamily within the forkhead box (FOX) protein family, which is a family of transcription factors that contain a forkhead DNA-binding domain. FOXO proteins regulate apoptosis, cell-cycle progression, oxidative-stress resistance, and tumor suppression. The transcriptional promoter activity of these factors is regulated by post-translational modifications, such as phosphorylation, acetylation, and monoubiquitination.;

NCIt note : There are four known members of the FOXO family expressed in humans. They are FOXO1, FOXO3, FOXO4 and FOXO6.;

Details

Origin ID

C118892;

UMLS CUI

C3899164;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_product_has_biochemical_function
- Transcription Factor [NCIt concept]
gene_product_has_structural_domain_or_motif
- Forkhead Box [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Transcriptional Activation [NCIt concept]
is_chemical_classification_of_gene_product
- Forkhead Box Protein O1 [NCIt concept]
- Forkhead Box Protein O3 [NCIt concept]
- Forkhead Box Protein O4 [NCIt concept]
- Forkhead Box Protein O6 [NCIt concept]

Keyword's position in hierarchy(ies) :

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