Forkhead Box Protein O3

Preferred Label : Forkhead Box Protein O3;

NCIt synonyms : Forkhead in Rhabdomyosarcoma-Like 1; AF6q21 Protein; Forkhead Box O3A; Forkhead Box Protein O3A; FOXO3A; Forkhead Box-O3A Protein; FOXO3;

NCIt definition : Forkhead box protein O3 (673 aa, 71 kDa) is encoded by the human FOXO3 gene. This protein is involved in the modulation of transcription, apoptosis and embryonic pattern formation.;

NCIt note : Forkhead box protein O3 recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. (UniProt);

Details

Origin ID

C28520;

UMLS CUI

C1333633;

OMIM relation
- Forkhead box o3a [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- FOXO3 protein, human [MeSH concept]
- FOXO3 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- FOXO3 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- FOXO Family [NCIt concept]
gene_product_has_structural_domain_or_motif
- Forkhead Box [NCIt concept]
gene_product_is_element_in_pathway
- AKT Signaling Pathway [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- Class I PI3K Signaling Pathway [NCIt concept]
- Endometrial Cancer Pathway [NCIt concept]
- FOXO Transcription Factor Family Signaling Pathway [NCIt concept]
- HDAC Class III Signaling Pathway [NCIt concept]
- IL2/PI3K Signaling Pathway [NCIt concept]
- Insulin Pathway [NCIt concept]
- Longevity Pathway [NCIt concept]
- Mast/Stem Cell Growth Factor Receptor Signaling Pathway [NCIt concept]
- NTRK1/PI3K/PLC-Gamma Signaling Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- Non-Small Cell Lung Cancer Pathway [NCIt concept]
- PTEN-Dependent Cell Cycle Arrest and Apoptosis Pathway [NCIt concept]
- Regulation of Apoptosis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- DNA Binding [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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