Forkhead Box Protein O1

Preferred Label : Forkhead Box Protein O1;

NCIt synonyms : Forkhead Box O1A; Forkhead in Rhabdomyosarcoma; Forkhead Box Protein O1A; FOXO1A; Forkhead Box-O1A Protein; FOXO1;

NCIt definition : Forkhead box protein O1 (655 aa, 70 kDa) is encoded by the human FOXO1 gene. This protein plays a role in the regulation of embryonic development, transcription and apoptosis.;

NCIt note : Forkhead Box O1 is a probable nuclear transcription factor (phosphorylated by AKT1; insulin-induced) that contains 1 forkhead domain and may play a role in myogenic growth and differentiation. Translocations of the FOXO1A gene - t(2;13)(q35;q14) or t(1;13)(p36;q14) - are associated with alveolar rhabdomyosarcoma-2 that produce FOXO1A/PAX3 and FOXO1A/PAX7 transcriptional activators.;

Details

Origin ID

C26207;

UMLS CUI

C0250455;

OMIM relation
- Forkhead box o1a [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- FOXO1 protein, human [MeSH Supplementary Concept]
- FOXO1 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- FOXO1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- FOXO Family [NCIt concept]
gene_product_has_structural_domain_or_motif
- Forkhead Box [NCIt concept]
gene_product_is_element_in_pathway
- AKT Signaling Pathway [NCIt concept]
- Androgen Receptor Regulation Pathway [NCIt concept]
- Angiopoietin-1 Receptor Signaling Pathway [NCIt concept]
- CXCR4-Mediated Signaling Pathway [NCIt concept]
- FOXO Transcription Factor Family Signaling Pathway [NCIt concept]
- HDAC Class III Signaling Pathway [NCIt concept]
- IL6-Mediated Signaling Pathway [NCIt concept]
- Insulin/Insulin Receptor Signaling Pathway [NCIt concept]
- Prostate Cancer Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Alveolar Rhabdomyosarcoma [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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