Growth Hormone Receptor

Preferred Label : Growth Hormone Receptor;

NCIt synonyms : Somatotropin Receptor; GHR; GH Receptor; GHRfl;

NCIt definition : Growth hormone receptor (638 aa, 72 kDa) is encoded by the human GHR gene. This protein is involved in somatotropin-dependent signaling and generalized growth.;

NCIt note : Growth hormone receptor can undergo cleavage after amino acid residue 253, which removes the transmembrane domain and produces a soluble protein called growth hormone-binding protein (GH-binding protein; GHBP; serum-binding protein). Growth hormone-binding protein plays a role as a reservoir of somatotropin in the plasma.; Growth hormone receptor is a type I membrane receptor for growth hormone with a ligand-binding extracellular domain (GHBP); a FnIII domain; a WSXWS motif; a cytoplasmic UbE motif for ubiquitination and internalization; and a cytoplasmic JAK interaction box 1 motif.;

Details

Origin ID

C41017;

UMLS CUI

C0122592;

Currated CISMeF NLP mapping
- Somatotropin receptor (substance) [SNOMED CT concept]
- receptors, somatotropin [MeSH Descriptor]
- receptors, somatotropin [MeSH concept]
False automatic mappings
- growth hormone receptor (1-241) [MeSH concept]
- growth hormone receptor (1-241) [MeSH Supplementary Concept]
OMIM relation
- Growth hormone receptor [OMIM Phenotype]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- GHR protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Receptor Gene [NCIt concept]
- GHR Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- AKT Signaling Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Growth Hormone Signaling Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- Mucosal Healing Pathway [NCIt concept]
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
- eIF4 Regulation Pathway [NCIt concept]
- mTOR Signaling Pathway BioCarta [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation Regulatory Process [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Generalized Growth [NCIt concept]
- Homodimerization [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Cimdelirsen [NCIt concept]
- Pegvisomant [NCIt concept]

Keyword's position in hierarchy(ies) :

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