Preferred Label : Pegvisomant;
NCIt synonyms : Somatotropin (18-Aspartic Acid, 21-Asparagine, 120-Lysine, 167-Asparagine, 168-Alanine,
171-Serine, 172-Arginine, 174-Serine, 179-Threonine) (Human), Pegylated;
NCIt definition : A pegylated, recombinant, human growth hormone (GH) structural analog with GH receptor
antagonist activity. As a GH analog, the structure of pegvisomant is similar to that
of native GH with the exception of 9 amino acid substitutions. Pegvisomant selectively
binds to GH receptors on cell surfaces, interfering with endogenous GH receptor binding
and so GH signal transduction. Inhibition of GH signal transduction results in decreased
serum concentrations of insulin-like growth factor-I (IGF-I), and other GH-responsive
serum proteins, including IGF binding protein-3 (IGFBP-3) and the acid-labile subunit
(ALS), and may inhibit the growth of cancers in which IGF-1 is upregulated.;
UNII : N824AOU5XV;
CAS number : 218620-50-9;
Drug name : Somavert; Trovert;
Codes from synonyms : 50484;
Origin ID : C61881;
UMLS CUI : C0913469;
Automatic exact mappings (from CISMeF team)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_target
