Growth Hormone Signaling Pathway

Preferred Label : Growth Hormone Signaling Pathway;

Alternative definition : BIOCARTA: Growth hormone plays a major role in regulating growth during childhood and adolescence and also regulates metabolism. Defects in growth hormone signaling can result in dwarfism and decreases in growth hormone levels with age have been suggested to play a role in the reduced function of some physiological systems. Growth hormone signals a response in cells through the growth hormone receptor, a member of the cytokine receptor gene family. Growth hormone causes the receptor to dimerize, activating the JAK2 protein kinase. The activity of JAK2 mediates many of the downstream responses to growth hormone through phosphorylation of STAT transcription factors, MAP kinases, other kinase cascades and molecules involved in metabolism like IRS-1. Factors like SOCS and SHP-1 appear to play a role in the down regulation of signaling by growth hormone and cytokines. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_ghPathway;

Details

Origin ID

C39092;

UMLS CUI

C1512283;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-1 [NCIt concept]
- Cytokine-Inducible SH2-Containing Protein [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 [NCIt concept]
- Fibroblast Growth Factor Receptor 4 [NCIt concept]
- GTPase HRas [NCIt concept]
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]
- Growth Hormone Receptor [NCIt concept]
- Hepatocyte Nuclear Factor 1-Alpha [NCIt concept]
- Insulin [NCIt concept]
- Insulin Receptor [NCIt concept]
- Insulin Receptor Substrate 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
- RAF Proto-Oncogene Serine/Threonine-Protein Kinase [NCIt concept]
- SHC-Transforming Protein 1 [NCIt concept]
- Serum Response Factor [NCIt concept]
- Signal Transducer and Activator of Transcription 5B [NCIt concept]
- Somatotropin [NCIt concept]
- Son of Sevenless Homolog 1 [NCIt concept]
- Suppressor of Cytokine Signaling 1 [NCIt concept]
- Tyrosine-Protein Kinase JAK2 [NCIt concept]
- Tyrosine-Protein Phosphatase Non-Receptor Type 6 [NCIt concept]
pathway_has_gene_element
- CISH wt Allele [NCIt concept]
- GH1 wt Allele [NCIt concept]
- GHR wt Allele [NCIt concept]
- GRB2 wt Allele [NCIt concept]
- HNF1A wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- INS wt Allele [NCIt concept]
- INSR wt Allele [NCIt concept]
- IRS1 wt Allele [NCIt concept]
- JAK2 wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAP2K2 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PLCG1 wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]
- PTPN6 wt Allele [NCIt concept]
- RAF1 wt Allele [NCIt concept]
- SHC1 wt Allele [NCIt concept]
- SOCS1 wt Allele [NCIt concept]
- SOS1 wt Allele [NCIt concept]
- SRF wt Allele [NCIt concept]
- STAT5B wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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