Integrin Beta-2

Preferred Label : Integrin Beta-2;

NCIt synonyms : Beta 2 Integrin Chain; CD11b Beta Subunit; ITGB2; CD11a Beta Subunit; Lymphocyte Function-Associated Cell Surface Adhesion Glycoprotein; LFA-1/CR3/P150, 959 Beta Subunit Precursor; CD11c Beta Subunit; CD18 Antigen; Leukocyte Cell Adhesion Molecule CD18; Cell Surface Adhesion Glycoproteins LFA-1/CR3/P150,95 Subunit Beta; Complement Receptor C3 Subunit Beta; Complement Receptor C3 Beta-Subunit;

NCIt definition : Integrin beta-2 (769 aa, 85 kDa) is encoded by the human ITGB2 gene. This protein is involved in complement C3 binding, leukocyte adhesion, and neutrophil chemotaxis.;

NCIt note : Leukocyte cell adhesion molecules belong to the glycoprotein integrin class of alpha-beta heterodimers. Integrin beta-2 chains are non-covalently linked to CD11 alpha chains, as in the integrin CR3 (CD11b/CD18) and the integrin CR4 (CD11c/CD18). JAB1 interacts with the LFA1 beta-2 (CD18) cytoplasmic domain. LFA1 engagement is followed by an increase of nuclear JAB1, enhanced DNA binding of AP1 complexes, and increased transactivation of target promoters.;

Details

Origin ID

C28489;

UMLS CUI

C4082564;

Currated CISMeF NLP mapping
- CD18 Antigens [MeSH Descriptor]
- CD18 Antigens [MeSH concept]
OMIM relation
- Integrin, beta-2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Receptor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cell Adhesion Molecule Gene [NCIt concept]
- ITGB2 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_expressed_in_tissue
- Leukocyte [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- AlphaM/Beta2 Integrin Signaling Pathway [NCIt concept]
- Amoebiasis Pathway [NCIt concept]
- CXCR3-Mediated Signaling Pathway [NCIt concept]
- Cell Adhesion Molecule Signaling Pathway [NCIt concept]
- HIF-1-Alpha Transcription Factor Pathway [NCIt concept]
- Leishmaniasis Infection Pathway [NCIt concept]
- Leukocyte Transendothelial Migration Pathway [NCIt concept]
- Malaria Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- Phagocytosis Pathway [NCIt concept]
- Viral Myocarditis Pathway [NCIt concept]
gene_product_is_physical_part_of
- Integrin AlphaL/Beta2 [NCIt concept]
- Integrin AlphaM/Beta2 [NCIt concept]
gene_product_malfunction_associated_with_disease
- Leukocyte Adhesion Deficiency Type 1 [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Cell-Cell Adhesion Process [NCIt concept]
- Chemotactic Process [NCIt concept]
- Heterodimerization [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients