Integrin AlphaL/Beta2

Preferred Label : Integrin AlphaL/Beta2;

NCIt synonyms : LFA1; Lymphocyte Function-Associated Antigen 1; LFA-1; CD11a/CD18; Integrin AlphaLBeta2; Lymphocyte Function-Associated Antigen-1; AlphaL/Beta2; LFA 1; Alpha-L/Beta-2; Integrin Alpha-L/Beta-2;

NCIt definition : Integrin alphaL/beta2 is a protein complex comprised of a heterodimer of integrin alphaL and integrin beta2. This complex is involved in leukocyte adhesion, cytolysis, helper T-cell interactions, and antibody-dependent killing by natural killer cells and granulocytes.;

NCIt note : Integrin alphaL/beta2 binds to ICAM-1 on antigen-presenting cells and functions as an adhesion molecule.;

Details

Origin ID

C97746;

UMLS CUI

C0079717;

Automatic exact mappings (from CISMeF team)
- Lymphocyte antigen CD11a (substance) [SNOMED CT concept]
- integrin subunit alpha L [HGNC gene]
- integrin subunit beta 2 [ORDO Gene]
- lymphocyte Function-Associated Antigen-1 [MeSH Descriptor]
- lymphocyte Function-Associated Antigen-1 [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- Leukocyte function associated antigen-1 adhesive protein (substance) [SNOMED CT concept]
- lfa-1 leukocyte adhesive protein [SNOMED Notion]
- lymphocyte Function-Associated Antigen-1 [MeSH Descriptor]
- lymphocyte Function-Associated Antigen-1 [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Adhesion Molecule [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Cell-Mediated Cytotoxicity [NCIt concept]
- Cytolytic Process [NCIt concept]
- Leukocyte Trafficking [NCIt concept]
- Ligand Binding [NCIt concept]
has_gene_product_element
- Integrin Alpha-L [NCIt concept]
- Integrin Beta-2 [NCIt concept]
related_to_genetic_biomarker
- ITGAL Gene [NCIt concept]
- ITGB2 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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