Preferred Label : lymphocyte Function-Associated Antigen-1;
MeSH definition : An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN
comprises the alpha chain and the CD18 antigen (ANTIGENS, CD18) the beta chain. Lymphocyte
function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES.
It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation,
helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS
and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for
lymphocyte function-associated antigen-1.; An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN
comprises the alpha chain and the CD18 antigen (CD18 ANTIGENS) the beta chain. Lymphocyte
function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES.
It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation,
helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS
and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for
lymphocyte function-associated antigen-1.;
MeSH synonym : alphalbeta2, integrin; antigen-1, lymphocyte function-associated; leukocyte function associated antigen-1; integrin alphalbeta2; LFA-1; Lymphocyte Function Associated Antigen 1;
MeSH annotation : DF: LFA1 or LFA 1;
Is substance : O;
Origin ID : D016169;
UMLS CUI : C0079717;
Allowable qualifiers
Currated CISMeF NLP mapping
Indexing information
Record concept(s)
See also
Semantic type(s)
UMLS correspondences (same concept)
An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN
comprises the alpha chain and the CD18 antigen (ANTIGENS, CD18) the beta chain. Lymphocyte
function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES.
It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation,
helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS
and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for
lymphocyte function-associated antigen-1.
An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN
comprises the alpha chain and the CD18 antigen (CD18 ANTIGENS) the beta chain. Lymphocyte
function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES.
It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation,
helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS
and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for
lymphocyte function-associated antigen-1.