Myosin-6 - CISMeF

Preferred Label : Myosin-6;

NCIt synonyms : Myosin Heavy Chain, Cardiac Muscle Alpha Isoform; Myosin Heavy Chain 6; MyHC-Alpha; MYH6; Cardiac Alpha-Myosin; Myosin 6;

NCIt definition : Myosin-6 (1939 aa, 224 kDa) is encoded by the human MYH6 gene. This protein is involved in cardiac muscle contraction and the structure of the sarcomere.;

NCIt note : Myosin-6 (cardiac alpha- myosin) is a candidate autoantigen for immune checkpoint inhibitor-associated myocarditis (ICI-MC). (Nature. 2022; 611:818-826. doi: 10.1038/s41586-022-05432-3.);

PubMed : 36385524;

Details

Origin ID

C200339;

UMLS CUI

C1437984;

OMIM relation
- Myosin, heavy chain 6, cardiac muscle, alpha [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MYH6 protein, human [MeSH Supplementary Concept]
- MYH6 protein, human [MeSH concept]
gene_encodes_gene_product
- Cytoskeletal Gene [NCIt concept]
- MYH6 Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_expressed_in_tissue
- Myocardium [NCIt concept]
gene_product_has_associated_anatomy
- Cytoskeleton [NCIt concept]
- Myofilament [NCIt concept]
- Sarcomere [NCIt concept]
gene_product_has_biochemical_function
- ATPase [NCIt concept]
- Actin-Binding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- SH3 Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cardiac Muscle Contraction Pathway [NCIt concept]
- Dilated Cardiomyopathy Pathway [NCIt concept]
- Hypertrophic Cardiomyopathy Pathway [NCIt concept]
- Viral Myocarditis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- ATP Hydrolysis [NCIt concept]
- Cardiac Muscle Contraction [NCIt concept]
- Cell Movement Process [NCIt concept]
- Cytoskeletal Modeling [NCIt concept]
- Cytoskeletal Process [NCIt concept]
- Myogenesis [NCIt concept]
- Regulation of Cell Shape [NCIt concept]

Keyword's position in hierarchy(ies) :

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