Dovitinib - CISMeF

Preferred Label : Dovitinib;

NCIt definition : A benzimidazole-quinolinone compound and receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Dovitinib binds to and inhibits the phosphorylation of type III-V RTKs, such as vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) that promote tumor cell proliferation and survival in certain cancer cells. In addition, this agent also inhibits other members of the RTK superfamily, including fibroblast growth factor receptor 1 and 3, FMS-like tyrosine kinase 3, stem cell factor receptor (c-KIT), and colony stimulating factor receptor 1. This may further lead to a reduction of cellular proliferation and angiogenesis, and an induction of tumor cell apoptosis.;

UNII : I35H55G906;

InChIKey : PIQCTGMSNWUMAF-UHFFFAOYSA-N;

CAS number : 405169-16-6;

Chemical formula : C21H21FN6O;

Codes from synonyms : 168;

Details

Origin ID

C76199;

UMLS CUI

C2699806;

Automatic exact mappings (from CISMeF team)
- 4-amino-5-fluoro-3-(5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl)quinolin-2(1H)-one [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- dovitinib [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- dovitinib [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Dovitinib Lactate [NCIt concept]
has_target
- Fibroblast Growth Factor Receptor 1 [NCIt concept]
- Fibroblast Growth Factor Receptor 3 [NCIt concept]
- Macrophage Colony-Stimulating Factor 1 Receptor [NCIt concept]
- Mast/Stem Cell Growth Factor Receptor Kit [NCIt concept]
- Platelet-Derived Growth Factor Receptor [NCIt concept]
- Vascular Endothelial Growth Factor Receptor [NCIt concept]
is_free_acid_or_base_form_of
- Dovitinib Lactate [NCIt concept]

Keyword's position in hierarchy(ies) :

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