Orantinib - CISMeF

Preferred Label : Orantinib;

NCIt synonyms : Orantinibum; 3-(2,4-Dimethyl-5-((2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-1H-pyrrol-3-yl)propionic Acid;

NCIt related terms : SU006668; SU6668; SU 6668;

NCIt definition : An orally bioavailable receptor tyrosine kinase inhibitor. SU6668 binds to and inhibits the autophosphorylation of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor (PDGFR), and fibroblast growth factor receptor (FGFR), thereby inhibiting angiogenesis and cell proliferation. SU6668 also inhibits the phosphorylation of the stem cell factor receptor tyrosine kinase c-kit, often expressed in acute myelogenous leukemia cells. (NCI04);

Alternative definition : NCI-GLOSS: A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called angiogenesis inhibitors.;

UNII : 9RL37ZZ665;

InChIKey : NHFDRBXTEDBWCZ-ZROIWOOFSA-N;

CAS number : 252916-29-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 252916-29-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : TSU 68; Sugen SU6668; SU6668;

Chemical formula : C18H18N2O3;

NSC code : 702827;

Codes from synonyms : CDR0000413731; 31700; CDR0000045045;

Details

Origin ID

C1884;

UMLS CUI

C0960373;

Automatic exact mappings (from CISMeF team)
- SU 6668 [MeSH concept]
- orantinib [MeSH concept]
- orantinib [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- orantinib [MeSH concept]
- orantinib [MeSH Supplementary Concept]
chemical_or_drug_affects_cell_type_or_tissue
- Endothelial Cell [NCIt concept]
chemical_or_drug_affects_gene_product
- Fibroblast Growth Factor Receptor Family [NCIt concept]
- Platelet-Derived Growth Factor Receptor [NCIt concept]
- Vascular Endothelial Growth Factor Receptor [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Receptor Tyrosine Kinase Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Inhibition of Cell Proliferation [NCIt concept]
- Negative Regulation of Angiogenesis [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Vascular Permeability Alteration [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Fibroblast Growth Factor Receptor 1 [NCIt concept]
- Platelet-Derived Growth Factor Receptor Beta [NCIt concept]
- Vascular Endothelial Growth Factor Receptor 2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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