Preferred Label : Resigratinib;
NCIt synonyms : Pan-fibroblast Growth Factor Receptor Inhibitor KIN-3248; Pan FGFR Inhibitor KIN-3248; Pan-FGFR Inhibitor KIN-3248;
NCIt definition : An orally bioavailable, small molecule, irreversible pan-inhibitor of fibroblast growth
factor receptor (FGFR) family proteins, with potential antineoplastic activity. Upon
oral administration, resigratinib covalently binds to and inhibits all four FGFR subtypes,
FGFR1, FGFR2, FGFR3 and FGFR4, including wild-type FGFR family proteins, and FGFR2
and FGFR3 gatekeeper, molecular brake, and activation loop mutations. This prevents
FGFR-mediated signaling, and inhibits both tumor angiogenesis and proliferation of
FGFR-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases upregulated
in many tumor cell types, plays a key role in cellular proliferation, cell survival
and angiogenesis.;
UNII : W728TB393W;
Molecule name : KIN 3248; KIN-3248;
NCI Metathesaurus CUI : CL1799095;
Origin ID : C190684;
UMLS CUI : C5783016;
Semantic type(s)
- concept_is_in_subset
- has_target
