Infigratinib - CISMeF

Preferred Label : Infigratinib;

NCIt synonyms : 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)-1-methylurea;

NCIt definition : An orally bioavailable pan inhibitor of human fibroblast growth factor receptors (FGFRs) with potential antiangiogenic and antineoplastic activities. Infigratinib selectively binds to and inhibits the activities of FGFRs, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. FGFRs are a family of receptor tyrosine kinases which may be upregulated in various tumor cell types and may be involved in tumor cell differentiation and proliferation, tumor angiogenesis, and tumor cell survival.;

UNII : A4055ME1VK;

InChIKey : QADPYRIHXKWUSV-UHFFFAOYSA-N;

CAS number : 872511-34-7;

Molecule name : BGJ-398; BGJ 398;

ChEBI ID : CHEBI:63451;

Codes from synonyms : 272;

Details

Origin ID

C88302;

UMLS CUI

C3254591;

Automatic exact mappings (from CISMeF team)
- infigratinib [ATC Code]
Currated CISMeF NLP mapping
- infigratinib [MeSH Supplementary Concept]
- infigratinib [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea [MeSH concept]
- Infigratinib (substance) [SNOMED CT concept]
- Product containing infigratinib (medicinal product) [SNOMED CT concept]
- infigratinib [MeSH Supplementary Concept]
- infigratinib [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Infigratinib Mesylate [NCIt concept]
- Infigratinib Phosphate [NCIt concept]
has_target
- Fibroblast Growth Factor Receptor 1 [NCIt concept]
- Fibroblast Growth Factor Receptor 2 [NCIt concept]
- Fibroblast Growth Factor Receptor 3 [NCIt concept]
is_free_acid_or_base_form_of
- Infigratinib Mesylate [NCIt concept]
- Infigratinib Phosphate [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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