Infigratinib Phosphate

Preferred Label : Infigratinib Phosphate;

NCIt synonyms : N'-(2,6-Dichloro-3,5-dimethoxyphenyl)-N-(6-(4-(4-ethylpiperazin-1-yl)anilino)pyrimidin-4-yl)-N-methylurea Phosphate (1:1);

NCIt definition : The phosphate salt form of infigratinib, an orally bioavailable pan-inhibitor of human fibroblast growth factor receptors (FGFRs) with potential antiangiogenic and antineoplastic activities. Upon administration, infigratinib selectively binds to and inhibits the activities of FGFRs, which may result in the inhibition of angiogenesis and cell proliferation, and the induction of cell death in tumors with activating FGFR amplifications, mutations, or fusions. FGFRs are a family of receptor tyrosine kinases that are involved in tumor cell differentiation and proliferation, tumor angiogenesis, and tumor cell survival. Activating FGFR amplifications, mutations, or fusions occur in various cancer cell types.;

UNII : 58BH47BV6S;

InChIKey : GUQNHCGYHLSITB-UHFFFAOYSA-N;

CAS number : 1310746-10-1;

Drug name : Truseltiq;

NCI Metathesaurus CUI : CL1412340;

Details

Origin ID

C175088;

UMLS CUI

C5421156;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Infigratinib [NCIt concept]
has_target
- Fibroblast Growth Factor Receptor 2 [NCIt concept]
is_component_of_chemotherapy_regimen
- Infigratinib Regimen [NCIt concept]
is_salt_form_of
- Infigratinib [NCIt concept]

Keyword's position in hierarchy(ies) :

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