NCIt definition : The mesylate salt of infigratinib, an orally bioavailable pan-inhibitor of human fibroblast
growth factor receptors (FGFRs) with potential antiangiogenic and antineoplastic activities.
Upon administration, infigratinib selectively binds to and inhibits the activities
of FGFRs, which may result in the inhibition of tumor angiogenesis and tumor cell
proliferation, and the induction of tumor cell death. FGFRs are a family of receptor
tyrosine kinases which may be upregulated in various tumor cell types and may be involved
in tumor cell differentiation and proliferation, tumor angiogenesis, and tumor cell
survival.;
UNII : E223Z0KWCC;
InChIKey : BXJJFNXYWJLBOS-UHFFFAOYSA-N;
CAS number : 1310746-12-3;
Molecule name : BGJ 398 Mesylate; BGJ-398 Mesylate;
Semantic type(s)