Preferred Label : Indium In 111 Vofatamab;
NCIt synonyms : 111In-FPI-1967; 111In-vofatamab; [111In]-FPI-1967; [111In]-vofatamab;
NCIt definition : A radioimmunoconjugate composed of vofatamab, a human immunoglobulin G1 (IgG1) monoclonal
antibody directed against the fibroblast growth factor receptor type 3 (FGFR3) labeled,
via a bifunctional chelate, with the radioisotope indium In 111, with potential use
as an imaging agent upon single photon emission computed tomography/computed tomography
(SPECT/CT). Upon administration of Indium In 111 vofatamab, the vofatamab moiety specifically
targets and binds to FGFR3. Upon SPECT/CT imaging, FGFR3-expressing tumor cells can
be visualized. FGFR3, a receptor tyrosine kinase upregulated or mutated in many tumor
cell types, plays a key role in tumor cell proliferation.;
NCI Metathesaurus CUI : CL1793098;
Origin ID : C188264;
UMLS CUI : C5707687;
Semantic type(s)
- concept_is_in_subset
- has_target
