Skeletal Development

Preferred Label : Skeletal Development;

NCIt definition : Human Skeletal Development involves growth and differentiation of axial, limb, and cranial elements of the skeletal system. Axial vertebrae and ribs derive from cartilage precursors of the paired segmented paraxial mesodermal somite sclerotomes. Interdependent positional signaling by the apical ectodermal ridge, the posterior mesenchyme zone of polarizing activity, and the non ridge ectoderm coordinate limb bud outgrowth and patterning by migrated lateral plate mesoderm and somite cells. Proximal-distal differentiating mesenchymal cells condense to form the limb skeletal primordia. The skull forms by direct ossification of, or cartilage condensation from neural crest-derived, ectomesenchyme.;

Details

Origin ID

C20138;

UMLS CUI

C1160401;

Automatic exact mappings (from CISMeF team)
- bone development [MeSH Descriptor]
- skeletal system development [GO term]
Semantic type(s)
- Organism Function [UMLS semantic type]
UMLS correspondences (same concept)
- skeletal system development [GO term]
biological_process_has_result_anatomy
- Bone Tissue [NCIt concept]
- Organ [NCIt concept]
- Skeletal System [NCIt concept]
biological_process_involves_gene_product
- Alpha-2-HS-Glycoprotein [NCIt concept]
- Ankyrin Repeat Domain-Containing Protein 11 [NCIt concept]
- Annexin A2 [NCIt concept]
- Atypical Chemokine Receptor 4 [NCIt concept]
- Bone Morphogenetic Protein 1 [NCIt concept]
- Bone Morphogenetic Protein 2 [NCIt concept]
- Bone Morphogenetic Protein 3 [NCIt concept]
- Bone Morphogenetic Protein 4 [NCIt concept]
- Bone Morphogenetic Protein 5 [NCIt concept]
- Bone Morphogenetic Protein 6 [NCIt concept]
- Bone Morphogenetic Protein 8B [NCIt concept]
- Bone Morphogenetic Protein Receptor Type-1A [NCIt concept]
- Bone Morphogenetic Protein Receptor Type-2 [NCIt concept]
- Cadherin-11 [NCIt concept]
- Cartilage Oligomeric Matrix Protein [NCIt concept]
- Cellular Communication Network Factor 6 [NCIt concept]
- Collagen Alpha-1(II) Chain [NCIt concept]
- Dymeclin [NCIt concept]
- EvC Complex Member EVC [NCIt concept]
- Exostosin-1 [NCIt concept]
- Exostosin-2 [NCIt concept]
- Fibroblast Growth Factor Receptor 3 [NCIt concept]
- Growth/Differentiation Factor 11 [NCIt concept]
- Growth/Differentiation Factor 3 [NCIt concept]
- Growth/Differentiation Factor 5 [NCIt concept]
- Homeobox Protein Aristaless-Like 3 [NCIt concept]
- Homeobox Protein Aristaless-Like 4 [NCIt concept]
- Homeobox Protein Hox-A13 [NCIt concept]
- Homeobox Protein Hox-B6 [NCIt concept]
- Homeobox Protein Hox-D13 [NCIt concept]
- Insulin-Like Growth Factor-Binding Protein 4 [NCIt concept]
- Limbin [NCIt concept]
- Osteocalcin [NCIt concept]
- Paired Box Protein Pax-1 [NCIt concept]
- Paired Box Protein Pax-9 [NCIt concept]
- Parathyroid Hormone-Related Protein [NCIt concept]
- Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor [NCIt concept]
- Peptidyl-Prolyl Cis-Trans Isomerase B [NCIt concept]
- Periostin [NCIt concept]
- Phosphate-Regulating Neutral Endopeptidase PHEX [NCIt concept]
- Protein C-ets-2 [NCIt concept]
- Refilin-A [NCIt concept]
- Runt-Related Transcription Factor 2 [NCIt concept]
- Serine/Threonine-Protein Kinase 32B [NCIt concept]
- Small EDRK-Rich Factor 1 [NCIt concept]
- Suppressor of Fused Homolog [NCIt concept]
- T-Box Transcription Factor TBX3 [NCIt concept]
- T-Box Transcription Factor TBX4 [NCIt concept]
- Tolloid-Like Protein 1 [NCIt concept]
- Transcriptional Enhancer Factor TEF-3 [NCIt concept]
- Treacle Protein [NCIt concept]
- Tumor Necrosis Factor Ligand Superfamily Member 11 [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 11B [NCIt concept]
- Vitamin D3 Receptor [NCIt concept]
- Zinc Finger Transcription Factor Trps1 [NCIt concept]
biological_process_is_part_of_process
- Maturation [NCIt concept]
process_involves_gene
- AHSG Gene [NCIt concept]
- AHSG wt Allele [NCIt concept]
- ALX3 Gene [NCIt concept]
- ALX3 wt Allele [NCIt concept]
- ALX4 Gene [NCIt concept]
- ALX4 wt Allele [NCIt concept]
- ANKRD11 Gene [NCIt concept]
- ANKRD11 wt Allele [NCIt concept]
- ANXA2 Gene [NCIt concept]
- ANXA2 wt Allele [NCIt concept]
- BGLAP Gene [NCIt concept]
- BGLAP wt Allele [NCIt concept]
- BMP1 Gene [NCIt concept]
- BMP1 wt Allele [NCIt concept]
- BMP2 Gene [NCIt concept]
- BMP2 wt Allele [NCIt concept]
- BMP3 Gene [NCIt concept]
- BMP3 wt Allele [NCIt concept]
- BMP4 Gene [NCIt concept]
- BMP4 wt Allele [NCIt concept]
- BMP5 Gene [NCIt concept]
- BMP5 wt Allele [NCIt concept]
- BMP6 Gene [NCIt concept]
- BMP6 wt Allele [NCIt concept]
- BMP8B Gene [NCIt concept]
- BMP8B wt Allele [NCIt concept]
- BMPR1A Gene [NCIt concept]
- BMPR1A wt Allele [NCIt concept]
- BMPR1B Gene [NCIt concept]
- BMPR1B wt Allele [NCIt concept]
- BMPR2 Gene [NCIt concept]
- BMPR2 wt Allele [NCIt concept]
- Bone Morphogenetic Protein Receptor Gene [NCIt concept]
- CCN6 Gene [NCIt concept]
- CCN6 wt Allele [NCIt concept]
- CDH11 Gene [NCIt concept]
- CDH11 wt Allele [NCIt concept]
- COL2A1 Gene [NCIt concept]
- COL2A1 wt Allele [NCIt concept]
- COMP Gene [NCIt concept]
- COMP wt Allele [NCIt concept]
- DYM Gene [NCIt concept]
- DYM wt Allele [NCIt concept]
- ETS2 Gene [NCIt concept]
- ETS2 wt Allele [NCIt concept]
- EVC Gene [NCIt concept]
- EVC wt Allele [NCIt concept]
- EVC2 Gene [NCIt concept]
- EVC2 wt Allele [NCIt concept]
- EXT1 Gene [NCIt concept]
- EXT1 wt Allele [NCIt concept]
- EXT2 Gene [NCIt concept]
- EXT2 wt Allele [NCIt concept]
- FGFR3 Gene [NCIt concept]
- FGFR3 wt Allele [NCIt concept]
- GDF11 Gene [NCIt concept]
- GDF11 wt Allele [NCIt concept]
- GDF3 Gene [NCIt concept]
- GDF3 wt Allele [NCIt concept]
- GDF5 Gene [NCIt concept]
- GDF5 wt Allele [NCIt concept]
- HOXA13 Gene [NCIt concept]
- HOXA13 wt Allele [NCIt concept]
- HOXB6 Gene [NCIt concept]
- HOXB6 wt Allele [NCIt concept]
- HOXD13 Gene [NCIt concept]
- HOXD13 wt Allele [NCIt concept]
- PAX1 Gene [NCIt concept]
- PAX1 wt Allele [NCIt concept]
- PAX9 Gene [NCIt concept]
- PAX9 wt Allele [NCIt concept]
- PHEX Gene [NCIt concept]
- PHEX wt Allele [NCIt concept]
- POSTN Gene [NCIt concept]
- POSTN wt Allele [NCIt concept]
- PPIB Gene [NCIt concept]
- PPIB wt Allele [NCIt concept]
- PTH1R Gene [NCIt concept]
- PTH1R wt Allele [NCIt concept]
- PTHLH Gene [NCIt concept]
- PTHLH wt Allele [NCIt concept]
- RFLNA Gene [NCIt concept]
- RFLNA wt Allele [NCIt concept]
- RUNX2 Gene [NCIt concept]
- RUNX2 wt Allele [NCIt concept]
- SERF1A Gene [NCIt concept]
- SERF1A wt Allele [NCIt concept]
- SERF1B Gene [NCIt concept]
- SERF1B wt Allele [NCIt concept]
- STK32B Gene [NCIt concept]
- STK32B wt Allele [NCIt concept]
- SUFU Gene [NCIt concept]
- SUFU wt Allele [NCIt concept]
- TBX3 Gene [NCIt concept]
- TBX3 wt Allele [NCIt concept]
- TBX4 Gene [NCIt concept]
- TBX4 wt Allele [NCIt concept]
- TCOF1 Gene [NCIt concept]
- TCOF1 wt Allele [NCIt concept]
- TEAD4 Gene [NCIt concept]
- TEAD4 wt Allele [NCIt concept]
- TLL1 Gene [NCIt concept]
- TLL1 wt Allele [NCIt concept]
- TNFRSF11B Gene [NCIt concept]
- TNFRSF11B wt Allele [NCIt concept]
- TNFSF11 Gene [NCIt concept]
- TNFSF11 wt Allele [NCIt concept]
- VDR Gene [NCIt concept]
- VDR wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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