Collagen Alpha-1(II) Chain

Preferred Label : Collagen Alpha-1(II) Chain;

NCIt synonyms : Collagen II Alpha 1; Alpha 1 Type II Collagen; II Alpha-1; Collagen II (Alpha 1); Collagen II, Alpha-1 Polypeptide; Collagen Alpha-1 II Chain; Collagen Alpha-1 (II) Chain; COL2A1;

NCIt definition : Collagen alpha-1(II) chain (1487 aa, 142 kDa) is encoded by the human COL2A1 gene. This protein plays a role in both cartilage structure and skeletal development.;

NCIt note : Collagen XI is a heterotrimer composed of 3 alpha chains, XI alpha-1, XI alpha-2 and II alpha-1 (XI alpha-3). (UniProt); Collagen II is a homotrimer containing 3 II alpha-1 chains. (UniProt); Chondrocalcin is a fragment of collagen alpha (II) that may be involved in cartilage calcification.;

Details

Origin ID

C75319;

UMLS CUI

C2699403;

Automatic exact mappings (from CISMeF team)
- Type II collagen [FMA entity]
- collagen type ii [MeSH Descriptor]
False automatic mappings
- Collagen, type II, alpha-1 [OMIM Phenotype]
OMIM relation
- Collagen, type II, alpha-1 [OMIM Phenotype]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
gene_encodes_gene_product
- COL2A1 Gene [NCIt concept]
- Collagen Gene [NCIt concept]
- Extracellular Matrix Protein Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Matrix [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Movement [NCIt concept]
- Cell-Matrix Adhesion Process [NCIt concept]
- Morphogenesis [NCIt concept]
- Organogenesis [NCIt concept]
- Skeletal Development [NCIt concept]
- Wound Repair [NCIt concept]

Keyword's position in hierarchy(ies) :

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