Bone Morphogenetic Protein Receptor Type-1B

Preferred Label : Bone Morphogenetic Protein Receptor Type-1B;

NCIt synonyms : Activin Receptor-Like Kinase 6; BMP Type-1B Receptor; BMPR-1B; EC 2.7.11.30; Bone Morphogenetic Protein Receptor Type IB; CDw293; CDw293 Antigen; Bone Morphogenetic Protein Receptor, Type IB;

NCIt definition : Bone morphogenetic protein receptor type-1B (502 aa, 57 kDa) is encoded by the human BMPR1B gene. This protein is a receptor serine/threonine kinase and is involved in signal transduction.;

NCIt note : When ligand binding occurs, bone morphogenetic protein receptor, type IB protein forms a heteromeric complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors are responsible for regulating ligand binding and the respective type I receptors are required for downstream signaling. (SwissProt and Entrez Gene);

Details

Origin ID

C73561;

UMLS CUI

C1312140;

Currated CISMeF NLP mapping
- bone morphogenetic protein receptor, type IB [MeSH concept]
OMIM relation
- Bone morphogenetic protein receptor, type ib [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- BMPR1B protein, human [MeSH concept]
- BMPR1B protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- BMPR1B Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Serine/Threonine Kinase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- BMP Receptor Signaling Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- TGF-beta Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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