Tumor Necrosis Factor Receptor Superfamily Member 11B

Preferred Label : Tumor Necrosis Factor Receptor Superfamily Member 11B;

NCIt synonyms : TNFRSF11B; Osteoprotegerin; Osteoclastogenesis Inhibitory Factor;

NCIt definition : Tumor necrosis factor receptor superfamily member 11B (401 aa, 46 kDa) is encoded by the human TNFRSF11B gene. This protein plays a role in the negative regulation of both osteoblast differentiation and bone resorption.;

Details

Origin ID

C30111;

UMLS CUI

C1308614;

Currated CISMeF NLP mapping
- Osteoprotegerin [MedDRA Preferred Term]
- osteoprotegerin [MeSH Descriptor]
- osteoprotegerin [MeSH concept]
OMIM relation
- Tumor necrosis factor receptor superfamily, member 11b [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- TNFRSF11B protein, human [MeSH concept]
- TNFRSF11B protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- TNF Receptor Family Gene [NCIt concept]
- TNFRSF11B Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Regulator [NCIt concept]
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Cell Surface Receptor [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Death Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Homeostatic Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Skeletal Development [NCIt concept]
- Tumor Necrosis Factor Signaling Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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