osteoprotegerin

Preferred Label : osteoprotegerin;

MeSH definition : A secreted member of the TNF receptor superfamily that negatively regulates osteoclastogenesis. It is a soluble decoy receptor of RANK LIGAND that inhibits both CELL DIFFERENTIATION and function of OSTEOCLASTS by inhibiting the interaction between RANK LIGAND and RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B.;

MeSH synonym : fdcr-1 protein; follicular dendritic cell derived receptor 1; follicular dendritic cell-derived receptor-1; ocif protein; receptors, tumor necrosis factor, member 11b; tumor necrosis factor receptor superfamily, member 11b; tumor necrosis factor receptor 11b; fdcr 1 protein; osteoclastogenesis inhibitory factor;

Wikipedia link : https://en.wikipedia.org/wiki/Osteoprotegerin;

Is substance : O;

Details

Origin ID

D053244;

UMLS CUI

C0538161;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Osteoprotegerin [MedDRA Preferred Term]
- Tumor Necrosis Factor Receptor Superfamily Member 11B [NCIt concept]
Record concept(s)
- osteoprotegerin [MeSH concept]
Related MeSH Supplementary Concept(s)
- OPG-Fc fusion protein, rat [MeSH Supplementary Concept]
- TNFRSF11B protein, human [MeSH Supplementary Concept]
- Tnfrsf11b protein, mouse [MeSH Supplementary Concept]
- Tnfrsf11b protein, rat [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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