Runt-Related Transcription Factor 2

Preferred Label : Runt-Related Transcription Factor 2;

NCIt synonyms : Osteoblast-Specific Transcription Factor 2; Acute Myeloid Leukemia 3 Protein; SL3-3 Enhancer Factor 1 Alpha A Subunit; Oncogene AML-3; Polyomavirus Enhancer-Binding Protein 2 Alpha A Subunit; OSF-2; Core-Binding Factor Subunit Alpha-1; PEBP2-Alpha A; SL3/AKV Core-Binding Factor Alpha A Subunit; CBF-Alpha-1; PEA2-Alpha A; RUNX2;

NCIt definition : Runt-related transcription factor 2 (521 aa, 57 kDa) is encoded by the human RUNX2 gene. This protein plays a role in the regulation of both bone development and transcription.;

Details

Origin ID

C91787;

UMLS CUI

C1529564;

Currated CISMeF NLP mapping
- core binding factor alpha 1 subunit [MeSH Descriptor]
- core binding factor alpha 1 subunit [MeSH concept]
OMIM relation
- Runt-related transcription factor 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- RUNX2 protein, human [MeSH concept]
- RUNX2 protein, human [MeSH Supplementary Concept]
- core binding factor alpha 1 subunit [MeSH concept]
- core binding factor alpha 1 subunit [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- RUNX2 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- FGF Signaling Pathway [NCIt concept]
- Regulation of Nuclear SMAD2/3 Signaling Pathway [NCIt concept]
- Regulation of Retinoblastoma Protein Pathway [NCIt concept]
gene_product_is_physical_part_of
- Core-Binding Factor [NCIt concept]
gene_product_malfunction_associated_with_disease
- Cleidocranial Dysplasia [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Skeletal Development [NCIt concept]
- Transcription [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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