Core-Binding Factor

Preferred Label : Core-Binding Factor;

NCIt synonyms : CBF;

NCIt definition : CBF is an alpha/beta heterodimeric transcription factor involved in the transcriptional regulation of several genes important in hematopoiesis. The CBFalpha subunit binds directly to the enhancer core DNA sequence on target genes, whereas the beta subunit does not bind the DNA directly but increases the affinity and stabilizes the binding of the alpha subunit to the DNA.;

Details

Origin ID

C17683;

UMLS CUI

C0212320;

Currated CISMeF NLP mapping
- core binding factors [MeSH Descriptor]
- core binding factors [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- core binding factors [MeSH Descriptor]
- core binding factors [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Transcription Factor [NCIt concept]
gene_product_plays_role_in_biological_process
- Transcriptional Regulation [NCIt concept]
has_gene_product_element
- Core-Binding Factor Subunit Beta [NCIt concept]
- Runt-Related Transcription Factor 1 [NCIt concept]
- Runt-Related Transcription Factor 2 [NCIt concept]
- Runt-Related Transcription Factor 3 [NCIt concept]
related_to_genetic_biomarker
- CBFB Gene [NCIt concept]
- RUNX1 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients