Core-Binding Factor Subunit Beta

Preferred Label : Core-Binding Factor Subunit Beta;

NCIt synonyms : Polyomavirus Enhancer-Binding Protein 2 Beta Subunit; SL3-3 Enhancer Factor 1 Beta Subunit; Core-Binding Factor Beta Subunit; PEA2-Beta; Polyomavirus Enhancer Binding Protein 2 Beta Subunit; CBFB; Core-Binding Factor Beta; PEBP2B; SL3/AKV Core-Binding Factor Beta Subunit; SL3-3 Enhancer Factor 1 Subunit Beta; PEBP2-Beta; CBF-Beta; Polyomavirus Enhancer-Binding Protein 2-Beta;

NCIt definition : Core-binding factor subunit beta (182 aa, 22 kDa) is encoded by the human CBFB gene. This protein plays a role in transcriptional regulation.;

NCIt note : Part of the heterodimeric transcription factor Core-Binding Factor. CBF beta does not bind to DNA directly, but increases the affinity and stabilizes the binding of the CBF alpha (transcription factor AML1) for the CBF enhancer/promoter DNA site in TCR genes. CBF appears to regulate hematopoietic differentiation.;

Details

Origin ID

C18027;

UMLS CUI

C0526211;

Currated CISMeF NLP mapping
- core binding factor beta subunit [MeSH Descriptor]
- core binding factor beta subunit [MeSH concept]
OMIM relation
- Core-binding factor, beta subunit [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CBFB protein, human [MeSH concept]
- CBFB protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CBFB Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_is_element_in_pathway
- ATF-2 Transcription Factor Signaling Pathway [NCIt concept]
- Regulation of Nuclear SMAD2/3 Signaling Pathway [NCIt concept]
gene_product_is_physical_part_of
- Core-Binding Factor [NCIt concept]
gene_product_malfunction_associated_with_disease
- Acute Myelomonocytic Leukemia with Abnormal Eosinophils [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Hematopoietic Process [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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