" /> Runt-Related Transcription Factor 1 - CISMeF





Preferred Label : Runt-Related Transcription Factor 1;

NCIt synonyms : Acute Myeloid Leukemia 1 Protein; Oncogene AML-1; CBF-Alpha B; Acute Myeloid Leukemia-1 Protein; Core-Binding Factor, Runt Domain, Alpha Subunit 2; Polyomavirus Enhancer-Binding Protein 2 Alpha B Subunit; SL3/AKV Core-Binding Factor Alpha B Subunit; AML-1; AML1 Protein; PEA2-Alpha B; AML1; PEBP2-Alpha B; RUNX1; Core-Binding Factor Subunit Alpha-2; CBF-Alpha; SL3-3 Enhancer Factor 1 Alpha B Subunit; CBF-Alpha-2; Core-Binding Factor Alpha; Polyomavirus Enhancer Binding Protein 2 Alpha B Subunit; Core-Binding Factor Alpha B Subunit; CBFA2; AML-1 Protein;

NCIt definition : Runt-related transcription factor 1 (453 aa, 49 kDa) is encoded by the human RUNX1 gene. This protein is involved in the promotion of gene transcription and hematopoiesis.;

NCIt note : Part of the heterodimeric transcription factor Core-Binding Factor. The CBFalpha subunit binds directly to the enhancer core DNA sequence on target genes, whereas the beta subunit does not bind the DNA directly but increases the affinity and stabilizes the binding of the alpha subunit to the DNA.;

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16/05/2024


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