Acute Myeloid Leukemia with t(8;21)(q22; q22.1); RUNX1-RUNX1T1

Preferred Label : Acute Myeloid Leukemia with t(8;21)(q22; q22.1); RUNX1-RUNX1T1;

NCIt synonyms : Acute Myeloid Leukemia with t(8;21)(q22;q22); Acute Myeloid Leukemia with t(8;21)(q22;q22)(AML1(CBFa)/ETO); Acute Myeloid Leukemia with t(8;21)(q22;q22); RUNX1-RUNX1T1; Acute Myeloid Leukemia with t 8 21 q22 q22 AML1 CBFa ETO; Acute Myeloid Leukemia with t(8;21)(q22; q22.1); RUNX1::RUNX1T1; Acute Myeloid Leukemia with t(8;21)(q22; q22.1); RUNX1::RUNX1T1 Fusion; Acute Myeloid Leukemia with t(8;21)(q22; q22.1); RUNX1-RUNX1T1 Fusion; Acute Myeloid Leukemia, t(8;21)(q22;q22);

NCIt related terms : AML with t(8;21)(q22;q22.1); RUNX1-RUNX1T1; AML with t(8;21)(q22;q22), RUNX1 RUNX1T1; AML with t(8;21)(q22;q22); RUNX1-RUNX1T1;

NCIt definition : An acute myeloid leukemia with t(8;21)(q22; q22.1) giving rise to RUNX1/RUNX1T1 fusion transcript and showing maturation in the neutrophil lineage. The bone marrow and the peripheral blood show large myeloblasts with abundant basophilic cytoplasm, often containing azurophilic granules. This type of AML is associated with good response to chemotherapy and high complete remission rate.;

Alternative definition : NICHD: An acute myeloid leukemia (AML) associated with t(8;21)(q22;q22) resulting in RUNX1-RUNX1T1 fusion protein expression. This is seen in 12% of children with AML.;

Neoplastic status : Malignant;

ICD-O code : 9896/3;

Details

Origin ID

C9288;

UMLS CUI

C1292774;

Automatic exact mappings (from CISMeF team)
- Acute myeloid leukaemia with t(8;21)(q22;q22), RUNX1-RUNX1T1 [ICD-11 More detail]
- Acute myeloid leukaemia, t(8;21)(q22;q22) [ICD-11 Extension code]
- Acute myeloid leukemia with t(8;21)(q22;q22) RUNX1-RUNX1T1 (disorder) [SNOMED CT concept]
Currated CISMeF NLP mapping
- Acute myeloid leukemia with RUNX1::RUNX1T1 fusion (morphologic abnormality) [SNOMED CT concept]
- Acute myeloid leukemia, t(8;21)(q22;q22) [ICD-O code]
Disease excludes abnormal cell
- Neoplastic Lymphoblast [NCIt concept]
Disease excludes normal cell origin
- Lymphocyte [NCIt concept]
Disease may have findings
- Auer Rods Present [NCIt concept]
- Favorable Clinical Outcome [NCIt concept]
- Hypercellular Bone Marrow [NCIt concept]
- Myeloblasts 20 Percent or More of Bone Marrow Nucleated Cells [NCIt concept]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Has cytogenetic abnormalities
- Chromosomal Rearrangement [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Acute myeloid leukemia with RUNX1::RUNX1T1 fusion (morphologic abnormality) [SNOMED CT concept]
- Acute myeloid leukemia with t(8;21)(q22;q22) RUNX1-RUNX1T1 (disorder) [SNOMED CT concept]
- Acute myeloid leukemia, t(8;21)(q22;q22) [ICD-O code]
associated_with_malfunction_of_gene_product
- Runt-Related Transcription Factor 1 [NCIt concept]
concept_is_in_subset
- AML Authorized Value Terminology [NCIt concept]
- AML Disease Characteristics Table [NCIt concept]
- CPTAC Acute Myeloid Leukemia Baseline Form [NCIt concept]
- CPTAC Baseline Medical Forms Terminology [NCIt concept]
- CPTAC Terminology [NCIt concept]
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology Terminology [NCIt concept]
- Mapped ICDO3.1 Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology Terminology [NCIt concept]
- Mapped ICDO3.2 Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
- NICHD Terminology [NCIt concept]
- Pediatric Hematology-Oncology Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Chronic Clinical Course [NCIt concept]
- Cytogenetic Abnormalities Not Detected [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_has_abnormal_cell
- Leukemic Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloblast [NCIt concept]
- Neoplastic Myeloblast with Abundant Basophilic Cytoplasm [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
disease_has_finding
- Blasts 10 Percent or More of Bone Marrow Nucleated Cells [NCIt concept]
- Blasts 10 Percent or More of Peripheral Blood White Cells [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Recurrent Genetic Abnormalities Present [NCIt concept]
disease_has_molecular_abnormality
- Fusion Protein Expression [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Bone Marrow Stem Cell with Predominant Neutrophil Differentiation [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_mapped_to_gene
- RUNX1/RUNX1T1 Fusion Gene [NCIt concept]
- RUNX1T1 Gene [NCIt concept]
pathogenesis_of_disease_involves_gene
- RUNX1/RUNX1T1 Fusion Gene [NCIt concept]
- RUNX1T1 Gene [NCIt concept]
- RUNX1T1 wt Allele [NCIt concept]

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