RUNX1/RUNX1T1 Fusion Gene

Preferred Label : RUNX1/RUNX1T1 Fusion Gene;

NCIt synonyms : AML1/ETO Fusion Gene; AML-ETO Fusion Gene; ETO/AML Fusion Gene; AML1/MTG8; AML1-MTG8; AML/ETO Fusion Gene; RUNX1-RUNX1T1 Fusion Gene; RUNX1::RUNX1T1 Fusion Gene;

NCIt related terms : AML1-ETO;

NCIt definition : A fusion gene ( 4.3 kb) that results from a chromosomal translocation t(8;21)(q22;q22) which fuses the first 5 exons of the RUNX1 gene to exon 2 of the RUNX1T1 gene. This rearrangement is associated with acute myeloid leukemia.;

GenBank Accession Number : D13979;

Details

Origin ID

C99294;

UMLS CUI

C1851466;

Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CPTAC Acute Myeloid Leukemia Baseline Form [NCIt concept]
- CPTAC Baseline Medical Forms Terminology [NCIt concept]
- CPTAC Terminology [NCIt concept]
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- RUNX1/RUNX1T1 Fusion Protein [NCIt concept]
gene_has_abnormality
- t(8;21)(q22;q22) [NCIt concept]
gene_involved_in_molecular_abnormality
- AML1-ETO Fusion Protein Expression [NCIt concept]
- t(8;21)(q22;q22) [NCIt concept]
gene_involved_in_pathogenesis_of_disease
- Acute Myeloid Leukemia with t(8;21)(q22; q22.1); RUNX1-RUNX1T1 [NCIt concept]
gene_mapped_to_disease
- Acute Myeloid Leukemia with t(8;21)(q22; q22.1); RUNX1-RUNX1T1 [NCIt concept]
- Adult Acute Myeloid Leukemia with t(8;21); (q22; q22.1); RUNX1-RUNX1T1 [NCIt concept]
- Childhood Acute Myeloid Leukemia with t(8;21); (q22; q22.1); RUNX1-RUNX1T1 [NCIt concept]
gene_plays_role_in_process
- Transcriptional Repression [NCIt concept]
genetic_biomarker_related_to
- RUNX1/RUNX1T1 Fusion Positive [NCIt concept]
- t(8;21)(q22;q22.3)(RUNX1T1/RUNX1) Fusion Transcript in Blood or Tissue by FISH [NCIt concept]
related_to_genetic_biomarker
- RUNX1 Gene [NCIt concept]
- RUNX1T1 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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