Childhood Acute Myeloid Leukemia with t(8;21); (q22; q22.1); RUNX1-RUNX1T1

Preferred Label : Childhood Acute Myeloid Leukemia with t(8;21); (q22; q22.1); RUNX1-RUNX1T1;

NCIt synonyms : Childhood Acute Myeloid Leukemia with t(8;21)(q22; q22.1); RUNX1::RUNX1T1; Childhood Acute Myeloid Leukemia with t(8;21); (q22; q22.1); RUNX1-RUNX1T1 Fusion; Childhood Acute Myeloid Leukemia with t(8;21); (q22; q22.1); RUNX1::RUNX1T1 Fusion;

NCIt definition : An acute myeloid leukemia with t(8;21)(q22; q22.1); RUNX1-RUNX1T1 occurring in children.;

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL1793583;

Details

Origin ID

C188450;

UMLS CUI

C5707782;

Disease excludes abnormal cell
- Neoplastic Lymphoblast [NCIt concept]
Disease excludes normal cell origin
- Lymphocyte [NCIt concept]
Disease may have findings
- Auer Rods Present [NCIt concept]
- Favorable Clinical Outcome [NCIt concept]
- Hypercellular Bone Marrow [NCIt concept]
- Myeloblasts 20 Percent or More of Bone Marrow Nucleated Cells [NCIt concept]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Has cytogenetic abnormalities
- Chromosomal Rearrangement [NCIt concept]
- t(8;21)(q22;q22) [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Chronic Clinical Course [NCIt concept]
- Cytogenetic Abnormalities Not Detected [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_has_abnormal_cell
- Leukemic Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloblast [NCIt concept]
- Neoplastic Myeloblast with Abundant Basophilic Cytoplasm [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
disease_has_finding
- Blasts 10 Percent or More of Bone Marrow Nucleated Cells [NCIt concept]
- Blasts 10 Percent or More of Peripheral Blood White Cells [NCIt concept]
- Childhood Lesion [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Recurrent Genetic Abnormalities Present [NCIt concept]
disease_has_molecular_abnormality
- AML1-ETO Fusion Protein Expression [NCIt concept]
- Fusion Protein Expression [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Bone Marrow Stem Cell with Predominant Neutrophil Differentiation [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_mapped_to_gene
- RUNX1/RUNX1T1 Fusion Gene [NCIt concept]
- RUNX1T1 Gene [NCIt concept]

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