t(8;21)(q22;q22)

Preferred Label : t(8;21)(q22;q22);

NCIt synonyms : Eight-Twenty-One; t 8 21 q22 q22; t(8;21)(q21.3;q22); t(8;21)(q22; q22.1);

NCIt definition : A cytogenetic abnormality that involves a translocation between 8q22 and 21q22. It is associated with the development of acute myeloid leukemia with RUNX1-RUNX1T1 fusion protein expression.;

Details

Origin ID

C13395;

UMLS CUI

C1515794;

Semantic type(s)
- Cell or Molecular Dysfunction [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
cytogenetic_abnormality_involves_chromosome
- Human Chromosome 21 [NCIt concept]
- Human Chromosome 8 [NCIt concept]
is_abnormality_of_gene
- RUNX1/RUNX1T1 Fusion Gene [NCIt concept]
is_cytogenetic_abnormality_of_disease
- Adult Acute Myeloid Leukemia with t(8;21); (q22; q22.1); RUNX1-RUNX1T1 [NCIt concept]
- Childhood Acute Myeloid Leukemia with t(8;21); (q22; q22.1); RUNX1-RUNX1T1 [NCIt concept]
may_be_cytogenetic_abnormality_of_disease
- Blastic Granulocytic Sarcoma [NCIt concept]
- Core Binding Factor Acute Myeloid Leukemia [NCIt concept]
- Differentiated Granulocytic Sarcoma [NCIt concept]
- Granulocytic Sarcoma [NCIt concept]
- Immature Granulocytic Sarcoma [NCIt concept]
- Mediastinal Granulocytic Sarcoma [NCIt concept]
molecular_abnormality_involves_gene
- RUNX1 Gene [NCIt concept]
- RUNX1/RUNX1T1 Fusion Gene [NCIt concept]
- RUNX1T1 Gene [NCIt concept]

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