core binding factor alpha 2 subunit

Preferred Label : core binding factor alpha 2 subunit;

MeSH definition : A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain. Runx1 is frequently mutated in human LEUKEMIAS.;

MeSH synonym : core-binding factor alpha 2 protein; runt related transcription factor 1; runx1 protein; pebp2a2 protein; runt-related transcription factor 1; acute myeloid leukemia 1 protein; core binding factor alpha 2 protein;

MeSH hyponym : acute myeloid leukemia 1d protein; acute myeloid leukemia 1c protein; acute myeloid leukemia 1b protein; acute myeloid leukemia 1a protein; acute myeloid leukemia 1D protein; acute myeloid leukemia 1C protein; acute myeloid leukemia 1A protein; acute myeloid leukemia 1B protein; AML1D Protein; AML1C Protein; AML1B Protein; AML1A Protein;

MeSH annotation : see SCR for organism-specific terms;

Is substance : O;

Details

Origin ID

D050676;

UMLS CUI

C0215508;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Runt-Related Transcription Factor 1 [NCIt concept]
Record concept(s)
- acute myeloid leukemia 1A protein [MeSH concept]
- acute myeloid leukemia 1B protein [MeSH concept]
- acute myeloid leukemia 1C protein [MeSH concept]
- acute myeloid leukemia 1D protein [MeSH concept]
- core binding factor alpha 2 subunit [MeSH concept]
Related MeSH Supplementary Concept(s)
- AML1-AMP19 fusion protein, human [MeSH Supplementary Concept]
- AML1-ETO fusion protein, human [MeSH Supplementary Concept]
- AML1-FOG2 fusion protein, human [MeSH Supplementary Concept]
- AML1-MDS1-EVI1 fusion protein, human [MeSH Supplementary Concept]
- AML1-MTG16 protein, human [MeSH Supplementary Concept]
- CBFA2-EAP fusion protein, human [MeSH Supplementary Concept]
- CBFA2-MDS1 protein, human [MeSH Supplementary Concept]
- RUNX1 protein, human [MeSH Supplementary Concept]
- Runx1 protein, mouse [MeSH Supplementary Concept]
- Runx1 protein, rat [MeSH Supplementary Concept]
- TEL-AML1 fusion protein [MeSH Supplementary Concept]
- TEL-RUNX1 fusion protein, human [MeSH Supplementary Concept]
- runx1 protein, zebrafish [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Runt-Related Transcription Factor 1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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