TNFSF11 wt Allele

Preferred Label : TNFSF11 wt Allele;

NCIt synonyms : ODF; hRANKL2; OPGL; sOdf; Tumor Necrosis Factor (Ligand) Superfamily, Member 11 wt Allele; TRANCE; RANKL; OPTB2; Tumor Necrosis Factor (Ligand) Family, Member 11 Gene; CD254; Tumor Necrosis Factor Ligand Superfamily, Member 11 Gene;

NCIt definition : Human TNFSF11 wild-type allele is located within 13q14 and is approximately 45 kb in length. This allele, which encodes tumor necrosis factor ligand superfamily member 11 protein, plays a role in osteoclast differentiation and activation. This allele also is involved in apoptotic signal transduction and regulation.;

GenBank Accession Number : NM_003701;

Details

Origin ID

C50965;

UMLS CUI

C1704863;

Automatic exact mappings (from CISMeF team)
- Osteopetrosis, autosomal recessive 2 [OMIM Phenotype]
- Outer dense fiber of sperm tails 1 [OMIM gene]
- TNF superfamily member 11 [ORDO Gene]
- Trance [MedDRA Preferred Term]
- Tumor necrosis factor ligand superfamily, member 11 [OMIM gene]
- autosomal recessive osteopetrosis 2 [DO Concept]
- orthodontics [MeSH Descriptor]
- rank ligand [MeSH Descriptor]
- receptor activator of nuclear factor-kappa B [MeSH Descriptor]
- superoxide dismutase activity [GO term]
OMIM relation
- Tumor necrosis factor ligand superfamily, member 11 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 13q14 [NCIt concept]
gene_is_element_in_pathway
- Bone Remodeling Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- IL6-Mediated Signaling Pathway [NCIt concept]
gene_plays_role_in_process
- Apoptosis [NCIt concept]
- Cell Death Process [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Homeostatic Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Skeletal Development [NCIt concept]
- Tumor Necrosis Factor Receptor Binding [NCIt concept]
- Tumor Necrosis Factor Signaling Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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