Growth/Differentiation Factor 11

Preferred Label : Growth/Differentiation Factor 11;

NCIt synonyms : Bone Morphogenetic Protein-11; Growth/Differentiation Factor-11; GDF-11; Bone Morphogenetic Protein 11; BMP-11; GDF11;

NCIt definition : Growth/differentiation factor 11 (407 aa, 45 kDa) is encoded by the human GDF11 gene. This protein plays a role in patterning of mesodermal, neural and skeletal tissues during development.;

NCIt note : Growth/differentiation factor 11 is a preproprotein that is proteolytically processed to generate an inactive disulfide-linked homodimer comprised of the mature C-terminal portion of the molecule bound non-covalently to its N-terminal propeptide. Activation requires proteolytic removal of the N-terminal propeptide.;

Details

Origin ID

C148355;

UMLS CUI

C1453137;

Automatic exact mappings (from CISMeF team)
- Growth/differentiation factor 11 [OMIM gene]
- growth differentiation factor 11 [HGNC gene]
OMIM relation
- Growth/differentiation factor 11 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- GDF11 protein, human [MeSH concept]
- GDF11 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Bone Morphogenetic Protein Gene [NCIt concept]
- GDF11 Gene [NCIt concept]
- Growth Factor Gene [NCIt concept]
- Transforming Growth Factor-Beta Family Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Signaling Protein [NCIt concept]
- Transforming Growth Factor [NCIt concept]
gene_product_is_biomarker_type
- Disease Marker [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Developmental Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Pattern Formation [NCIt concept]
- Receptor Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Skeletal Development [NCIt concept]

Keyword's position in hierarchy(ies) :

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