Tumor Necrosis Factor Ligand Superfamily Member 11

Preferred Label : Tumor Necrosis Factor Ligand Superfamily Member 11;

NCIt synonyms : ODF; OPGL; TNF-Related Activation-Induced Cytokine; Osteoclast Differentiation Factor; Osteoprotegerin Ligand; TNFSF11; TRANCE; RANKL; Receptor Activator of Nuclear Factor Kappa B Ligand; Receptor Activator of Nuclear Factor Kappa-B Ligand; CD254; CD254 Antigen; Receptor Activator of NF-Kappa-B Ligand;

NCIt definition : Tumor necrosis factor ligand superfamily member 11 (317 aa, 35 kDa) is encoded by the human TNFSF11 gene. This protein is involved in osteoclast differentiation and activation and the regulation of the interactions between T-cells and dendritic cells.;

NCIt note : Tumor necrosis factor ligand superfamily member 11 binds as an osteoclast activation and differentiation ligand to TNFRSF11B/OPG and to TNFRSF11A/RANK. Isoforms 1 and 3 are type II membrane proteins; isoform 2 is secreted. A soluble form of isoform 1 is likely derived from proteolytic processing by ADAM17. TNFSF11 activates antiapoptotic kinase AKT/PKB through a SRC kinase/TRAF6 signaling complex and augments or regulates dendritic cell stimulation of naive T-cell proliferation.;

Details

Origin ID

C30113;

UMLS CUI

C0666361;

Automatic exact mappings (from CISMeF team)
- RANK ligand [MeSH concept]
- TNF superfamily member 11 [ORDO Gene]
- Tumor necrosis factor ligand superfamily, member 11 [OMIM gene]
- orthodontics [MeSH Descriptor]
- rank ligand [MeSH Descriptor]
- receptor activator of nuclear factor-kappa B [MeSH Descriptor]
Currated CISMeF NLP mapping
- Osteoclast differentiation factor [MedDRA LLT]
- Osteoprotegerin ligand [MedDRA Preferred Term]
- Trance [MedDRA Preferred Term]
OMIM relation
- Tumor necrosis factor ligand superfamily, member 11 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TNFSF11 protein, human [MeSH concept]
- TNFSF11 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Gene [NCIt concept]
- TNFSF11 Gene [NCIt concept]
- Tumor Necrosis Factor Family Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Regulator [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Bone Remodeling Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- IL6-Mediated Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Cell Death Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Homeostatic Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Skeletal Development [NCIt concept]
- Tumor Necrosis Factor Receptor Binding [NCIt concept]
- Tumor Necrosis Factor Signaling Process [NCIt concept]
is_target
- Anti-RANKL Monoclonal Antibody HS-20090 [NCIt concept]
- Denosumab [NCIt concept]
- Narlumosbart [NCIt concept]

Keyword's position in hierarchy(ies) :

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