Bone Morphogenetic Protein Receptor

Preferred Label : Bone Morphogenetic Protein Receptor;

NCIt synonyms : BMPR; BMPR Protein; Bone Morphogenetic Protein Receptor Protein;

NCIt definition : Receptor serine/threonine kinase proteins with a cysteine-rich extracellular domain, a single transmembrane domain and a cytoplasmic serine threonine kinase domain that bind to certain members of the transforming growth factor beta family, including bone morphogenetic proteins, and initiate downstream intracellular signaling pathways. These receptors are involved in the development of bone and cartilage and the establishment and maintenance of tissue architecture.;

Détails

Origin ID

C212142;

concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Pediatric Oncology Biomarkers/Targets Associated with Other Relevant Evidence [NCIt concept]
gene_encodes_gene_product
- Bone Morphogenetic Protein Receptor Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Serine/Threonine Kinase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
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- Transmembrane Protein [NCIt concept]
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- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Histogenic Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Skeletal Development [NCIt concept]

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