Growth/Differentiation Factor 5

Preferred Label : Growth/Differentiation Factor 5;

NCIt synonyms : GDF5 Protein; GDF5; Growth Differentiation Factor 5; Bone Morphogenetic Protein 14; GDF-5; CDMP-1; Cartilage-Derived Morphogenetic Protein-1; Cartilage-Derived Morphogenetic Protein 1; LPS-Associated Protein 4; Lipopolysaccharide-Associated Protein 4; Growth Differentiation Factor-5; LAP-4; BMP-14;

NCIt definition : Growth/differentiation factor 5 (501 aa, 55 kDa) is encoded by the human GDF5 gene. This protein is involved in skeletal development.;

NCIt note : The active growth factor is released from the precursor following proteolytic cleavage at arginine at amino acid position 381 which is the final amino acid in a polybasic proteolytic processing site. (EntrezGene and UniProt); Growth/differentiation factor 5 is predominantly expressed in long bones during human embryonic development.;

Details

Origin ID

C26322;

UMLS CUI

C2003595;

Currated CISMeF NLP mapping
- growth differentiation factor 5 [MeSH Descriptor]
- growth differentiation factor 5 [MeSH concept]
OMIM relation
- Growth/differentiation factor 5 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- GDF5 protein, human [MeSH concept]
- GDF5 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- GDF5 Gene [NCIt concept]
- Growth Factor Gene [NCIt concept]
- Transforming Growth Factor-Beta Family Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Transforming Growth Factor [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_biomarker_type
- Disease Marker [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- TGF-beta Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Receptor Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Skeletal Development [NCIt concept]

Keyword's position in hierarchy(ies) :

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