Vitamin D3 Receptor

Preferred Label : Vitamin D3 Receptor;

NCIt synonyms : Cholecalciferol Receptor; Receptors, Calcitriol; 1,25-Dihydroxyvitamin D3 Receptor; VDR; Nuclear Receptor Subfamily 1 Group I Member 1; Calcitriol Receptor; Vitamin D Receptor; Protein Phosphatase 1, Regulatory Subunit 163; Vitamin D Hormone Receptor; Vitamin-D3 Receptor; NR1I1;

NCIt definition : Vitamin D3 receptor (427 aa, 48 kDa) is encoded by the human VDR gene. This protein is involved in vitamin D-mediated transcriptional regulation.;

NCIt note : Vitamin D3 receptor dimerizes with retinoic acid receptor RXR-alpha after vitamin D binds. (UniProt); Vitamin D3 Receptors are cytoplasmic polypeptides that specifically bind 1,25(OH)2D3, migrate to the nucleus, and regulate transcription of specific target genes to produce a variety of biologic effects. The VDR protein belongs to the steroid superfamily of trans-acting transcriptional regulatory factors and is most closely related to the thyroid hormone receptors. VDR residues immediately N-terminal of the first DNA-binding zinc finger are vital for contact with TFIIB. (from OMIM 601769);

Details

Origin ID

C17485;

UMLS CUI

C3657722;

Currated CISMeF NLP mapping
- receptors, calcitriol [MeSH Descriptor]
- receptors, calcitriol [MeSH concept]
OMIM relation
- Vitamin D receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- VDR protein, human [MeSH concept]
- VDR protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- Nuclear Receptor Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
- VDR Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Hormone Receptor [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- Nuclear Hormone Receptor Superfamily [NCIt concept]
gene_product_has_structural_domain_or_motif
- Hormone Receptor DNA-Binding Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
- Tumor Marker [NCIt concept]
gene_product_is_element_in_pathway
- Gene Expression Regulation by Vitamin D Receptor Pathway [NCIt concept]
- Lipid Metabolism and Toxicity Pathway [NCIt concept]
- RXR and RAR Heterodimerization with Other Nuclear Receptor Signaling Pathway [NCIt concept]
- Regulation of Nuclear SMAD2/3 Signaling Pathway [NCIt concept]
- Retinoic Acid Receptor Family-Mediated Signaling Pathway [NCIt concept]
- p53 Effector Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- DNA Binding [NCIt concept]
- Homeostatic Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Maturation [NCIt concept]
- Pattern Formation [NCIt concept]
- Receptor Signaling [NCIt concept]
- Skeletal Development [NCIt concept]
- Tissue Growth [NCIt concept]
- Transcriptional Regulation [NCIt concept]
is_target
- Cholecalciferol [NCIt concept]
- Doxercalciferol [NCIt concept]
- Ergocalciferol [NCIt concept]
- Inecalcitol [NCIt concept]

Keyword's position in hierarchy(ies) :

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