Cholecalciferol

Preferred Label : Cholecalciferol;

NCIt synonyms : Delsterol; Calciol; 9,10-Secocholesta-5,7,10(19)-trien-3-beta-ol; (3beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol;

NCIt related terms : 9,10-Secocholesta-5,7,10(19)-trien-3-ol; Vitamin D3;

NCIt definition : A steroid hormone produced in the skin when exposed to ultraviolet light or obtained from dietary sources. The active form of cholecalciferol, 1,25-dihydroxycholecalciferol (calcitriol) plays an important role in maintaining blood calcium and phosphorus levels and mineralization of bone. The activated form of cholecalciferol binds to vitamin D receptors and modulates gene expression. This leads to an increase in serum calcium concentrations by increasing intestinal absorption of phosphorus and calcium, promoting distal renal tubular reabsorption of calcium and increasing osteoclastic resorption.;

Alternative definition : CRCH: Vitamin D synthesized from ergosterol in yeast and plants.; NCI-GLOSS: A nutrient that the body needs in small amounts to function and stay healthy. Cholecalciferol helps the body use calcium and phosphorus to make strong bones and teeth. It is fat-soluble (can dissolve in fats and oils) and is found in fatty fish, egg yolks, and dairy products. Skin exposed to sunshine can also make cholecalciferol. Not enough cholecalciferol can cause a bone disease called rickets. It is being studied in the prevention and treatment of some types of cancer.;

UNII : 1C6V77QF41;

InChIKey : QYSXJUFSXHHAJI-YHJXBONMSA-N;

CAS number : 67-97-0;

Unit used : mcg;

Chemical formula : C27H44O;

NSC code : 375571;

ChEBI ID : CHEBI:28940;

Codes from synonyms : CDR0000427252; 00678; NSC0375571;

Details

Origin ID

C48194;

UMLS CUI

C0008318;

Automatic exact mappings (from CISMeF team)
- vitamin d [MedlinePlus Topic]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
- Vitamin [UMLS semantic type]
UMLS correspondences (same concept)
- Cholecalciferol [ICD-11 Extension code]
- Cholecalciferol [LOINC component]
- Colecalciferol (substance) [SNOMED CT concept]
- Product containing colecalciferol (medicinal product) [SNOMED CT concept]
- Vitamin D3 [ICD-11 Extension code]
- activated 7-dehydrocholesterol preparation [SNOMED Notion]
- cholecalciferol [Substance BNPC]
- cholecalciferol [MeSH concept]
- cholecalciferol [MeSH Descriptor]
- colecalciferol [ATC Code]
- vitamin d3 [SNOMED Notion]
Validated automatic mappings to BTNT
- colecalciferol [ATC Code]
Validated automatic mappings to NTBT
- cholecalciferols [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_target
- Vitamin D3 Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

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