Inecalcitol - CISMeF

Preferred Label : Inecalcitol;

NCIt synonyms : (7E)-19-Nor-9,10-seco-14beta-cholesta-5,7-dien-23-yne-1alpha,3beta,25-triol; ICC;

NCIt definition : An analog of calcitriol and a vitamin D3 receptor (VDR) agonist, with potential antineoplastic activity. Upon administration, inecalcitol targets and binds to VDR. This activates VDR and VDR-mediated signal transduction pathways. This modulates the VDR-mediated expression of certain genes, including the expression of anti-cancer genes, enhances cellular differentiation, induces tumor cell apoptosis and inhibits tumor cell growth. VDR plays a central role in calcium homeostasis and in the growth of certain cancer cells.;

UNII : 05FZV98342;

InChIKey : HHGRMHMXKPQNGF-WNSNRMDMSA-N;

CAS number : 163217-09-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 163217-09-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : TX 522;

Chemical formula : C26H40O3;

Details

Origin ID

C83818;

UMLS CUI

C2827203;

Automatic exact mappings (from CISMeF team)
- Cirrhosis, familial [OMIM Phenotype]
- Insertion of pleural tube drain (procedure) [SNOMED CT concept]
- TX 522 [MeSH concept]
- calcium channel blockers [MeSH Descriptor]
- heart failure [MeSH Descriptor]
- inecalcitol [MeSH Supplementary Concept]
- inecalcitol [MeSH concept]
- intrahepatic cholangiocarcinoma [Radlex concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
- Vitamin [UMLS semantic type]
UMLS correspondences (same concept)
- inecalcitol [MeSH concept]
- inecalcitol [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Vitamin D3 Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

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