" /> TNFRSF11B wt Allele - CISMeF





Preferred Label : TNFRSF11B wt Allele;

NCIt synonyms : Tumor Necrosis Factor Receptor Superfamily, Member 11B (Osteoprotegerin) Gene; MGC29565; TR1; OCIF; OPG; PDB5; Tumor Necrosis Factor Receptor Superfamily, Member 11b Gene; TNF Receptor Superfamily Member 11b wt Allele;

NCIt definition : Human TNFRSF11B wild-type allele is located in the vicinity of 8q24 and is approximately 29 kb in length. This allele, which encodes tumor necrosis factor receptor superfamily member 11B protein, plays a role in bone homeostasis through the mediation of osteoclast apoptosis. Deletions and mutations in the gene are associated with juvenile Paget disease of the bone.;

NCIt note : Studies of the mouse counterpart also suggest this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their respective length is unknown.;

GenBank Accession Number : NM_002546;

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12/05/2024


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