Preferred Label : FGFR2/3 Inhibitor CGT4859;
NCIt synonyms : FGFR2/FGFR3 Inhibitor CGT4859;
NCIt definition : An orally bioavailable reversible inhibitor of fibroblast growth factor receptor (FGFR)
types 2 and 3 (FGFR2/3), with potential antineoplastic activity. Upon oral administration,
FGFR2/3 inhibitor CGT4859 targets, reversibly binds to and inhibits FGFR2/3, and is
specifically active against FGFR2 molecular brake and gatekeeper resistance mutations.
This blocks FGFR2/3-mediated signaling and leads to an inhibition of tumor cell proliferation
in FGFR2/3-overexpressing cells. FGFR, a family of receptor tyrosine kinases upregulated
in many tumor cell types, plays a key role in cellular proliferation, cell survival
and angiogenesis.;
Molecule name : CGT 4859; CGT-4859;
Origin ID : C213324;
concept_is_in_subset
- has_target
