Masitinib Mesylate

Preferred Label : Masitinib Mesylate;

NCIt synonyms : 4-[(4-Methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)-1,3-thiazol-2-yl]amino}phenyl)benzamide Mesylate;

NCIt definition : The orally bioavailable mesylate salt of masatinib, a multi-targeted protein tyrosine kinase inhibitor with potential antineoplastic activity. Masitinib selectively binds to and inhibits both the wild-type and mutated forms of the stem cell factor receptor (c-Kit; SCFR); platelet-derived growth factor receptor (PDGFR); fibroblast growth factor receptor 3 (FGFR3); and, to a lesser extent, focal adhesion kinase (FAK). As a consequence, tumor cell proliferation may be inhibited in cancer cell types that overexpress these receptor tyrosine kinases (RTKs).;

UNII : ZK89EG3A18;

CAS number : 1048007-93-7;

Molecule name : AB-1010; AB 1010;

Details

Origin ID

C79831;

UMLS CUI

C2698019;

Currated CISMeF NLP mapping
- masitinib mesylate [MeSH concept]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- masitinib mesylate [MeSH concept]
chemical_or_drug_has_mechanism_of_action
- Receptor Tyrosine Kinase Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Inhibition of Cell Proliferation [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Decernotinib [NCIt concept]
- Masitinib [NCIt concept]
has_target
- Fibroblast Growth Factor Receptor 3 [NCIt concept]
- Focal Adhesion Kinase 1 [NCIt concept]
- Mast/Stem Cell Growth Factor Receptor Kit [NCIt concept]
- Platelet-Derived Growth Factor Receptor [NCIt concept]
is_salt_form_of
- Decernotinib [NCIt concept]
- Masitinib [NCIt concept]

Keyword's position in hierarchy(ies) :

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