Masitinib - CISMeF

Preferred Label : Masitinib;

NCIt synonyms : 4-((4-Methylpiperazin-1-yl)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)-1,3-thiazol-2-yl)amino)phenyl)benzamide;

NCIt definition : A multi-targeted protein tyrosine kinase inhibitor, with potential antineoplastic activity. Upon administration, masitinib selectively binds to and inhibits both the wild-type and mutated forms of the stem cell factor receptor (c-Kit; SCFR); platelet-derived growth factor receptor (PDGFR); fibroblast growth factor receptor 3 (FGFR3); and, to a lesser extent, focal adhesion kinase (FAK). As a consequence, tumor cell proliferation may be inhibited in cancer cell types that overexpress these receptor tyrosine kinases (RTKs).;

UNII : M59NC4E26P;

InChIKey : WJEOLQLKVOPQFV-UHFFFAOYSA-N;

CAS number : 790299-79-5;

Chemical formula : C28H30N6OS;

ChEBI ID : CHEBI:63450;

Codes from synonyms : 321;

Details

Origin ID

C79910;

UMLS CUI

C2351398;

Automatic exact mappings (from CISMeF team)
- Masitinib [ICD-11 Extension code]
- masitinib [ATC Code]
Currated CISMeF NLP mapping
- Masitinib [Substance BNPC]
- masitinib [MeSH concept]
- masitinib [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- masitinib [ATC Code]
- masitinib [MeSH concept]
- masitinib [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Receptor Tyrosine Kinase Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Inhibition of Cell Proliferation [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
has_salt_form
- Masitinib Mesylate [NCIt concept]
is_free_acid_or_base_form_of
- Masitinib Mesylate [NCIt concept]

Keyword's position in hierarchy(ies) :

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