" /> Masitinib - CISMeF





Preferred Label : Masitinib;

NCIt synonyms : 4-((4-Methylpiperazin-1-yl)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)-1,3-thiazol-2-yl)amino)phenyl)benzamide;

NCIt definition : A multi-targeted protein tyrosine kinase inhibitor, with potential antineoplastic activity. Upon administration, masitinib selectively binds to and inhibits both the wild-type and mutated forms of the stem cell factor receptor (c-Kit; SCFR); platelet-derived growth factor receptor (PDGFR); fibroblast growth factor receptor 3 (FGFR3); and, to a lesser extent, focal adhesion kinase (FAK). As a consequence, tumor cell proliferation may be inhibited in cancer cell types that overexpress these receptor tyrosine kinases (RTKs).;

UNII : M59NC4E26P;

InChIKey : WJEOLQLKVOPQFV-UHFFFAOYSA-N;

CAS number : 790299-79-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 790299-79-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C28H30N6OS;

ChEBI ID : CHEBI:63450;

Codes from synonyms : 321;

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19/05/2024


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