Preferred Label : FGFR3 Inhibitor LOXO-435;
NCIt synonyms : FGFR3 Inhibitor LY3866288;
NCIt definition : An orally bioavailable, selective inhibitor of human fibroblast growth factor receptor
3 (FGFR3), with potential antineoplastic activity. Upon oral administration, FGFR3
inhibitor LOXO-435 specifically targets and binds to FGFR3, including FGFR3 gatekeeper
resistance mutations. This blocks FGFR3-mediated signaling and leads to an inhibition
of tumor cell proliferation in FGFR3-overexpressing cells. FGFR3, a receptor tyrosine
kinase, is involved in angiogenesis and in the proliferation, differentiation, and
survival of tumor cells. FGFR3 expression is associated with poor prognosis. It is
overexpressed and/or mutated by certain tumor cell types.;
Molecule name : LOX-24350; LOXO-435; LY 3866288; LY-3866288; LOX 24350; LOXO 435;
NCI Metathesaurus CUI : CL1912566;
Origin ID : C192227;
UMLS CUI : C5784997;
Semantic type(s)
- concept_is_in_subset
- has_target
