Aprutumab Ixadotin

Preferred Label : Aprutumab Ixadotin;

NCIt synonyms : ADC BAY1187982;

NCIt definition : An antibody-drug conjugate (ADC) directed against the fibroblast growth factor receptor type 2 (FGFR2) and conjugated to an as of yet unidentified toxin, with potential antineoplastic activity. Upon intravenous administration, aprutumab ixadotin binds to FGFR2. Upon binding, the toxin selectively induces cell death, through an as of yet undisclosed mechanism of action, in FGFR2-expressing tumor cells. FGFR2, a receptor tyrosine kinase upregulated in many tumor cell types, plays an essential role in tumor cell proliferation, differentiation and survival.;

UNII : DDD2AB5TWK;

CAS number : 1708947-48-1;

Molecule name : BAY 1187982; BAY1187982;

Details

Origin ID

C121212;

UMLS CUI

C4724805;

Automatic exact mappings (from CISMeF team)
- aprutumab ixadotin [MeSH concept]
Currated CISMeF NLP mapping
- aprutumab ixadotin [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- aprutumab ixadotin [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Fibroblast Growth Factor Receptor 2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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