Preferred Label : Aprutumab Ixadotin;
NCIt synonyms : ADC BAY1187982;
NCIt definition : An antibody-drug conjugate (ADC) directed against the fibroblast growth factor receptor
type 2 (FGFR2) and conjugated, via a non-cleavable linker, to BAY 1168650, an auristatin
W derivative and microtubule-disrupting cytotoxic agent, with potential antineoplastic
activity. Upon intravenous administration, aprutumab ixadotin binds to FGFR2. Upon
binding, BAY 1168650 targets and binds to tubulin, and inhibits microtubule polymerization.
This results in G2/M phase cell cycle arrest and apoptosis in FGFR2-expressing tumor
cells. FGFR2, a receptor tyrosine kinase upregulated in many tumor cell types, plays
an essential role in tumor cell proliferation, differentiation and survival.;
UNII : DDD2AB5TWK;
CAS number : 1708947-48-1;
Molecule name : BAY 1187982; BAY1187982;
Origin ID : C121212;
UMLS CUI : C4724805;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
