NCIt definition : An antibody-drug conjugate (ADC) directed against the fibroblast growth factor receptor
type 2 (FGFR2) and conjugated to an as of yet unidentified toxin, with potential antineoplastic
activity. Upon intravenous administration, aprutumab ixadotin binds to FGFR2. Upon
binding, the toxin selectively induces cell death, through an as of yet undisclosed
mechanism of action, in FGFR2-expressing tumor cells. FGFR2, a receptor tyrosine kinase
upregulated in many tumor cell types, plays an essential role in tumor cell proliferation,
differentiation and survival.;
UNII : DDD2AB5TWK;
CAS number : 1708947-48-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1708947-48-1
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