NCIt definition : The hydrochloride salt form of lirafugratinib, an orally bioavailable inhibitor of
the fibroblast growth factor receptor 2 (FGFR2), with potential antineoplastic activity.
Upon oral administration, lirafugratinib binds to and inhibits FGFR2, which results
in the inhibition of FGFR2-mediated signal transduction pathways. This inhibits the
proliferation of FGFR2-overexpressing tumor cells. FGFR2, a receptor tyrosine kinase
upregulated in many tumor cell types, plays a key role in cellular proliferation,
migration and survival.;
Semantic type(s)