Preferred Label : Lirafugratinib Hydrochloride;
NCIt synonyms : RLY4008 Hydrochloride; RLY 4008 Hydrochloride; RLY-4008 Hydrochloride;
NCIt definition : The hydrochloride salt form of lirafugratinib, an orally bioavailable inhibitor of
the fibroblast growth factor receptor 2 (FGFR2), with potential antineoplastic activity.
Upon oral administration, lirafugratinib binds to and inhibits FGFR2, which results
in the inhibition of FGFR2-mediated signal transduction pathways. This inhibits the
proliferation of FGFR2-overexpressing tumor cells. FGFR2, a receptor tyrosine kinase
upregulated in many tumor cell types, plays a key role in cellular proliferation,
migration and survival.;
UNII : 4P76F4XM3B;
CAS number : 2688040-45-9;
NCI Metathesaurus CUI : CL1799382;
Origin ID : C190744;
UMLS CUI : C5783899;
Semantic type(s)
- concept_is_in_subset
- has_target
