Preferred Label : Lirafugratinib;
NCIt synonyms : Fibroblast Growth Factor Receptor 2 Inhibitor RLY-4008; FGFR2 Inhibitor RLY-4008;
NCIt definition : An orally bioavailable inhibitor of the fibroblast growth factor receptor 2 (FGFR2),
with potential antineoplastic activity. Upon oral administration, lirafugratinib binds
to and inhibits FGFR2, which results in the inhibition of FGFR2-mediated signal transduction
pathways. This inhibits the proliferation of FGFR2-overexpressing tumor cells. FGFR2,
a receptor tyrosine kinase upregulated in many tumor cell types, plays a key role
in cellular proliferation, migration and survival.;
UNII : 7HY6IMH87S;
CAS number : 2549174-42-5;
Molecule name : RLY-4008; RLY 4008;
NCI Metathesaurus CUI : CL1411775;
Origin ID : C174208;
UMLS CUI : C5787315;
Semantic type(s)
- concept_is_in_subset
- has_target
